Association of Vitamin D with Cardiovascular Disease
DOI:
https://doi.org/10.69591/jcihs.v1i1.2Keywords:
25(OH) D, Cardiovascular Diseases, Deficiency, BloodAbstract
Objective: To investigate the relationship between vitamin D level in serum and cardiovascular diseases.
Study Design: Prospective study.
Place and duration: Study was conducted in Choudhary Parvez Ellahi Institute of Cardiology in one year duration from 1st February 2020 to 1st February 2021.
Methodology: One hundred and fifty patients presented with cardiac illness at emergency department were enrolled in study. The serum levels of vitamin D were divided into three categories: deficiency, insufficiency, and sufficiency. SPSS version 23 was used for data analysis. P value ≤0.5 was taken as significant.
Results: Serum 25(OH) D levels in both the groups were shown in table 3. In the non-CVD Group, 48% of patients were 25(OH)D deficient. 56% of patients had insufficient and (40%) patients had sufficient serum 25(OH)D levels. While, in CVD Group, n=44 (58.6%) patients were 25(OH)D deficient. 37.3% of patients had insufficient, and 61.3% patients had sufficient serum 25(OH)D levels. The results were statistically significant.
Conclusion: Lower levels of serum 25-hydroxy vitamin D were associated with higher rates of cardiovascular diseases. Further studies are needed to recommend vitamin D supplements to reduce the risk of cardiovascular diseases
References
Raja Chakraverty and Pranabesh Chakraborty. “Recent Insights into the Role of Vitamin B12 and Vitamin D upon Cardiovascular Mortality: A Systematic Review”. Acta Scientific Pharmaceutical Sciences 2018;2(12):61-65.
Wimalawansa SJ. Vitamin D and cardiovascular diseases: Causality. J Steroid Biochem Mol Biol. 2018;175:29-43. doi: 10.1016/j.jsbmb.2016.12.016.
Rai V, Agrawal DK. Role of Vitamin D in Cardiovascular Diseases. Endocrinol Metab Clin North Am. 2017;46(4):1039–1059. doi:10.1016/j.ecl.2017.07.009
Chen S, Swier VJ, Boosani CS, Radwan MM, Agrawal DK. Vitamin D Deficiency Accelerates Coronary Artery Disease Progression in Swine. Arterioscler Thromb Vasc Biol. 2016;36(8):1651–9.
Li DM, Zhang Y, Li Q, Xu XH, Ding B, Ma JH. Low 25-Hydroxyvitamin D Level Is Associated with Peripheral Arterial Disease in Type 2 Diabetes Patients. Arch Med Res. 2016;47(1):49–54.
Oh SH, Kweon SS, Choi JS, Rhee JA, Lee YH, Nam HS, et al. Association between Vitamin D Status and Risk of Peripheral Arterial Disease: The Dong-gu Study. Chonnam Med J. 2016;52(3):212–6.
Lupton JR, Faridi KF, Martin SS, Sharma S, Kulkarni K, Jones SR, et al. Deficient serum 25-hydroxyvitamin D is associated with an atherogenic lipid profile: The Very Large Database of Lipids (VLDL-3) study. Journal of clinical lipidology. 2016;10(1):72–81.
Aleksova A, Beltrami AP, Belfiore R, Barbati G, Di Nucci M, Scapol S, et al. U-shaped relationship between vitamin D levels and long-term outcome in large cohort of survivors of acute myocardial infarction. Int J Cardiol. 2016;223:962–6.
Batra CM, Agarwal R. Hypocalcemic Cardiomyopathy and Pseudohypoparathyroidism Due to Severe Vitamin D Deficiency. J Assoc Physicians India. 2016;64(6):74–6.
Hannesdottir T, Hrafnkelsson H, Johannsson E, Sigurdsson EL. [The relationship between serum vitamin D levels and cardiovascular risk factors among Icelandic children]. Laeknabladid. 2017; 103 (9):367–71. https://doi.org//10.17992/lbl.2017.09.149
Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008; 117(4):503–11. https://doi.org/10.1161/ CIRCULATIONAHA.107.706127
Chen YH, Fu L, Hao JH, Yu Z, Zhu P, Wang H, et al. Maternal vitamin D deficiency during pregnancy elevates the risks of small for gestational age and low birth weight infants in Chinese population. The Journal of clinical endocrinology and metabolism. 2015; 100(5):1912–9. https://doi.org/10.1210/jc. 2014-4407
Reis JP, von Muhlen D, Miller ERr, Michos ED, Appel. Vitamin D status and cardiometabolic risk factors in the United States adolescent population. Pediatrics. 2009; 124(3):e371–9. https://doi.org/10.1542/ peds.2009-0213
Kienreich K, Tomaschitz A, Verheyen N, Pieber T, Gaksch M, Grubler MR, et al. Vitamin D and cardiovascular disease. Nutrients. 2013; 5(8):3005–21. https://doi.org/10.3390/nu5083005
Ministry of Health of the People’s Republic of China (2011) China’s health statistics yearbook, 2011. Beijing: Peking Union Medical College Press (ISBN 978-7-81136-536-8) Page 290, 329. 2011
Kunutsor SK, Apekey TA, Steur M. Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants. Eur J Epidemiol. 2013; 28(3):205–21. https://doi.org/10.1007/s10654-013-9790-2
Raed A, Bhagatwala J, Zhu H, Pollock NK, Parikh SJ, Huang Y, et al. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial. PLoS One. 2017; 12(12):e0188424. https://doi.org/10.1371/journal. pone.0188424
Lu L, Yu Z, Pan A, Hu FB, Franco OH, Li H, et al. Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care. 2009; 32(7):1278– 83. https://doi.org/10.2337/dc09-0209
Kelishadi R, Salek S, Salek M, Hashemipour M, Movahedian M. Effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in children with metabolic syndrome: a triplemasked controlled trial. J Pediatr (Rio J). 2014; 90(1):28–34. https://doi.org/10.1016/j.jped.2013.06.006
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